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demonstrated that the supernatant of EcN protected the TJ barrier function in sepsis both in vivo and in vitro by inhibiting the increased NF-B-mediated activation of the MLCK-P-MLC signaling pathway

It is derived from a protective protein found naturally in human gastric juice, which contributes to gut mucosal integrity and tissue repair

A 5 mg reconstituted with bacteriostatic water yields about 2.5 mg/mL

On phase: up to 3 months of active dosing, following the Month 1 to Month 3 titration

Most published findings come from short-duration animal studies or small clinical cohorts, leaving questions about long-term effects, interactions with other compounds, and use across diverse populations largely unanswered

[PMC free article: PMC3758473] [PubMed: 18802415] 16