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Subgroup analysis on the design of randomized controlled trials, 3 studies with cross-over trials demonstrated the odds ratio of dialysis-related hypotension was 0.13 (95% CI [0.0063.10], p = 0.21, I 2 = 90%) comparing L-carnitine to placebo

The amount of cytochrome c oxidase negative muscle fibers in treated mice decreased by 30%, the citrate synthase activity in muscle as a marker of mitochondrial biogenesis was doubled, liver lipid levels were restored and muscle mitochondrial ultrastructure was normalized (no ragged red fiber-like muscle fibers or mitochondria with distorted structure and cristae on electron microscopy)

Maccari F, Arseni A, Chiodi P, Ramacci MT, Angelucci L: Levels of carnitines in brain and other tissues of rats of different ages: effect of acetyl-L-carnitine administration

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44 In contrast, Sanderson et al