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doi: 10.7150/thno.24945

Beyond their established use in sleep disorders, ramelteon alleviates experimental acute ocular inflammation via HIF-1/VEGF/E-NOS signaling (Usta Sofu et al., 2022), while agomelatine attenuates cisplatin-induced nephrotoxicity by suppressing NF-B-driven inflammation ( These advances are supported by systematic pharmacological reviews from our team and others (Ruan et al., 2021