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ALTERED MITOCHONDRIAL MORPHOLOGY AND FUNCTION Mitochondria are no longer considered as static spherical bodies, but highly dynamic organelles that readily fuse, divide, propagate, and diminish according to cellular requirements

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Assessments were conducted at baseline (week 0) and week 48

TNF- induces adipocytes to release free fatty acids, which in turn bind to Toll-like receptors on macrophages and adipocytes, further activating inflammatory signaling pathways and promoting the release of inflammatory factors (164)