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Pajarillo et al., 2022a), Yin Yang 1 (YY1) (Zhang et al., 2020) and nuclear factor erythroid 2-related factor 2 (Nrf2) ( Numerous studies have been conducted in search of potential therapeutics for Mns toxicity, including antioxidants, anti-inflammatory, and anti-excitotoxic agents

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However, whether berberine alleviates neurodegenerative disease symptoms by increasing neuroprotection requires further study