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Remarkably, KDS12025 demonstrated significant efficacy in mitigating RA pathology, as evidenced by a reduction in the CIA score, a clinical measure of joint inflammation severity, and improvements in histological parameters, including synovial hyperplasia and cartilage destruction, as shown via H&E and toluidine blue staining (Supplementary Fig

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Moreover, in a study on smokers, supplementation with Haematococcus -derived ASTA for three weeks at daily doses between 5 and 40 mg resulted in a dose-dependent reduction in F2-isoprostane levels, a lipid marker of oxidative stress [37]

Despite significant advances in mechanical treatments such as rotational atherectomy, these methods are passive treatments for advanced calcification (191)

Each of these RCD patterns is triggered and propagated through molecular pathways that exhibit significant connectivity (Tang et al., 2019) (Figure 2)

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