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Predominantly observed in bone marrow, lymph nodes, thymus, spleen and tonsils, CD38 is also present in not hematopoietic tissues such as male tissues in the prostate and seminal vesicles [3, 4] (Fig

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both NNMT and resveratrol modulate Sirtuin 1 (Sirt1) activity 83,84 , and resveratrol 83 and 5A-1MQ increase Parasutterella abundance, suggesting a potential causal link