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Thus far, approximately 40 companies worldwide, including Codiak Biosciences, Evox Therapeutics, Tavec Pharmaceuticals, Carmine Therapeutics, Anjarium, and Micromedmark Biotech, have developed exosome-based therapies, which are expected to provide cost-effective and more accurate targeted therapies in the clinic ( However, challenges, such as large-scale production, purity, and batch homogeneity of exosomes, still limit their clinical application

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Intraindividual variation reflects the temporal fluctuations in nutrient intake experienced by an individual, influenced by factors such as meals, timing, appetite, lifestyle adjustments, as well as biological ones (absorption, transport, metabolism, and excretion influenced by the physiology and the pathophysiology specific to each individual)

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