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6.4 Mitochondrial quality control: balancing protection and pathology during infection Mitophagy and mitochondrial biogenesis represent critical quality control processes

They are not approved for human or veterinary use and are not intended for diagnostic or therapeutic applications

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Accordingly, drug-tolerant persister cells are best understood as residual cancer cells that survive therapeutic exposure through reversible, non-genetic adaptive mechanisms, enabling persistence under treatment and re-entry into the cell cycle once therapeutic pressure is removed

doi: 10.1016/j.celrep.2024.114746 151 YabuT.ShimuzuA.YamashitaM

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