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Conceptual Origin: From Empirical Observation to Theoretical Framework In the 16th century, the Swiss physician Paracelsus established the philosophical foundation for dose-response relationships with his statement, The dose makes the poison ( Sola dosis facit venenum )

doi: 10.1111/hel.12741 141 PengX.ZhangR.DuanG.WangC.SunN.ZhangL.et al

Appendicular lean mass (ALM) was calculated as the sum of the lean soft tissue mass from all four limbs and was expressed in kilograms

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

By inducing degradation of cIAPs, SMAC mimetics triggers formation of the TRADD-RIPK1-FADD-caspase8 signaling complex, resulting in caspase 8 activation and apoptosis [167]