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Its pathogenesis is underpinned by a constellation of interrelated mechanismsprimarily hepatic lipid accumulation, oxidative stress, insulin resistance, mitochondrial dysfunction, chronic inflammation, alterations in gut microbiota, and genetic and epigenetic influences

The microbiome and risk for obesity and diabetes

TBBPA induced hepatocyte ferroptosis by PCBP1-mediated ferritinophagy

Carlberg EB

In contrast, pharmacological activation by CB1 agonists reduced the hormonal response to stress, indicating that the endocannabinoid system modulates the HPA axis (Patel et al., 2004)

Au(I)thiourea complexes contain Au atoms coordinated by two sulfur atoms and exhibit remarkable cytotoxicity against various tumor cell lines, as demonstrated by significantly increased ROS levels and disrupted mitochondrial membrane potential (MMP), which in turn leads to the release of cytochrome c and subsequent activation of caspases 9, 7, and 3 (Yu et al