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Jensen et al., 2015)

Among all phase I drug-metabolizing enzymes, cytochrome P450 enzymes (CYPs) play a key role in the metabolism of ACDs

And thats what they used to use it for

Int J Oncol 26: 14011410 Kang R, Tang D, Schapiro NE, Livesey KM, Farkas A, Loughran P, Bierhaus A, Lotze MT, Zeh HJ (2010a) The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

In addition, cholestatic liver injuries such as primary biliary cirrhosis and primary sclerosing cholangitis can also lead to an increase in AREG expression to protect hepatocytes from injury (Santamara et al., 2019)