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Estimation of intake and status of vitamin A, vitamin E and folate in older European adults: the ZENITH

Russell BJ, Brown SD, Siguenza N, Mai I, Saran AR, Lingaraju A, et al

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A 2008 study published in the Journal of Medicinal Chemistry demonstrated metabolic effects in rodent models at 50mg/kg, which led early researchers to extrapolate human-equivalent doses between 50100mg daily

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It is very hygroscopic in the anhydrous form, and moderately soluble in water