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Astrocytic chaperones and Parkinson Chaperones belonging to the conserved family of Heat shock proteins (Hsps) are proteins involved in the regulation of protein folding, translocation of proteins across membranes, regulation of cell death and assembling of protein [114]

The lactate produced by glycolysis is then transported out of astrocytes through monocarboxylate transporters (MCT1 and MCT4) and taken up by neurons via MCT2 (Figure 1)

Swisher SG , Hofstetter W, Wu TT, Correa AM, Ajani JA, Komaki RR, Chirieac L, Hunt KK, Liao Z, Phan A, Rice DC, Vaporciyan AA, Walsh GL, Roth JA

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This finding underscores the involvement of the glutamate signaling pathway in ALS (Spalloni et al., 2013)