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Combined use should always follow clinical assessment and should not replace investigation of underlying causes

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Safety Profile Across all six human trials and the extensive preclinical work, the safety picture is quite clean: No serious adverse events attributed to the compound No effect on IGF-1 No impairment of glucose tolerance or insulin sensitivity No genotoxic activity Most common side effects: mild injection site irritation, occasional headache or fatigue all transient This is genuinely one of the better-characterized peptides from a safety standpoint, largely because it actually went through a formal development process with proper clinical oversight

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Reference lists were also examined for any additional relevant studies not identified through the search

Lumbar epidural steroid injections are very precise, so healthcare providers performing the injection must have significant specialized training