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doi: 10.1093/oxfordjournals.humrep.a136174 68 La VigneraSCondorelliRAVicariETuminoDMorgiaGFavillaVet al

Beyond its canonical cGMP-dependent pathway, NO modulates cardiac and vascular function via S -nitrosylation as S -nitrosothiols (RSNOs) regulate protein activity and mitochondrial stability

This finding is in agreement with clinical findings that human nucleus pulposus (NP) fibrosis is essential for the maintenance of IVD height and mechanical properties in patients following percutaneous endoscopic lumbar discectomy (PELD)