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As alternative strategies avoiding animals, we mention the usage of: (i) In vitro cell and tissue culturesroutinely used for the preliminary screening of potential drug toxicity and involves the in vitro growth of animal/human cells outside the body in the laboratory environment

Oxid Med Cell Longev 2020:8294158

It has shown good effects on human skin

The role of iron and ferroptosis

Nonetheless, its application in GBM chemo-immunotherapy still faces the obstacle of a complex preparation process to protect the biofunction of antibodies

Remaining active sgRNAs exhibited a median KD efficiency of 72%, with comparable transcriptional responses to independent sgRNAs targeting the same promoter (Fig