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4.1.1 Basic function of the HPA axis When an individual confronts a stressor, the hypothalamic-pituitary-adrenal (HPA) axis initiates a stress response by a range of endocrine feedback mechanisms (Kageyama et al., 2021)

These compounds exhibit chemoprotective activity through a mechanism involving inhibition of cytochrome P450 and induction of GST and other enzymes [103,104]

This study identifies a comprehensive epigenetic mechanism by which dietary genistein exerts its chemopreventive effects on the colon during early stage carcinogenesis

FDA, July 2324, 2026 Pharmacy Compounding Advisory Committee meeting and introductory briefing document

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Although AHCY inhibitors show potential in the treatment of prostate cancer, the safety and side effects of their long-term use remain unclear