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Resetting the mitochondrial redox balance by exogenous application of GSH or with palmitate, mediated by the TrxR2/Trx2/Prx3 system, normalized excitation-contraction coupling, which led the authors to propose that the inability of the diabetic heart to deal with an increase in energy demand may result from a perturbation of the mitochondrial redox status [68]

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There is increasing evidence that NK cells link innate and adaptive immunity and play an important role in the pathogenesis of autoimmune conditions [176, 318]

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