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A1 (neurotoxic) and A2 (neuroprotective), which are also related to the production of proinflammatory or immunomodulatory mediators according to their polarization state (Stephenson et al., 2018)

Moreover, breakdown of epithelial and endothelial barriers allows microbial translocation from mucosal sites, especially the gut and sinuses, fueling systemic complement and cytokine cascades

Semax and selank, often used in nasal spray formulations , follow standard storage guidelines when reconstituted for injection use

However, gastrointestinal side effects were more frequent

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In the lungs, they modulate eicosanoid production, particularly resolvins and protectins, which help resolve inflammation and reduce tissue damage in respiratory diseases such as asthma, COPD, fibrosis, and acute respiratory infections [49,50,51]