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The advantages of microorganisms growing in the activated carbon layer was first affirmed by Parkhrust and his partners in 1967 [ 3 , 4 ] , this demonstration enabled the lengthening of the GAC's (Granular Activated Carbon) operation life to a great extent and Ozonation-Biological Activated Carbon technology was finally established

Subsequent animal experiments confirmed that OAFF could inhibit CXCL8 to maintain resting NPSCs through the PI3K-Akt-mammalian target of rapamycin (mTOR) signaling pathway, thereby inhibiting disease progression in a rat tail disc puncture model [441]

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doi: 10.1039/C8CP06280C [DOI] [PubMed] [Google Scholar] 11.Parchebafi A, Tamanaee F, Ehteram H, Ahmad E, Nikzad H, Haddad Kashani H