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No significant inter-group difference was observed with regard to the primary outcome (physical function on the Short-Form 36 subscale at 6 months) [168]

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Firstly, there is a scarcity of clinical studies investigating the effects of TCM on gut microbiota, with most studies conducted in animal models or in vitro settings

However, in controlled therapeutic settings, ozone therapy has demonstrated calculated oxidative stress induction, which activates therapeutic benefits without resulting in acute or chronic toxicity [29]

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