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In physiological settings wherein the GSH/GSSG redox couple is highly reduced, mammalian GLRX1 (hereafter referred to as GLRX) acts predominantly as a deglutathionylase 5

For comparison, and as a control to assess the specificity of BDNF among other known neuronal activity-regulated paracrine factors 1,2,3 , soluble NLGN3 was similarly tested and exerted no acute effect on glutamatergic current amplitude in glioma cells (Extended Data Fig

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doi: 10.1016/j.ecoenv.2020.110956 35 WangJZhuMWangLChenCSongY

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This is a key reason dosing should remain at or below the saturation threshold