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351 A global lactylome profiling of cancerous and adjacent tissues from 40 patients with gastrointestinal cancer also identified 11698 Kla sites, highlighting its role in cancer processes, including epigenetic rewiring, metabolic perturbations, and genome instability

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(4) This interaction may be crucial as FOXO4, when bound to p53, may inhibit some of p53's key functions involved in cell cycle regulation and apoptosis

The investigators reported partial restoration of the circadian melatonin rhythm in elderly subjects following the epithalamin course, with measurable but incomplete return toward younger-adult patterns of nocturnal melatonin secretion [2]

Furthermore, the incidence of the abnormal HPT axis also showed a decreasing trend, but with no statistical significance ( P = 0.093)