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However, a contradictory study shows that CCR2 [the receptor for CCL2 known to be expressed by microglia (van der Meer et al., 2000)] was detected in human fetal astrocytes and mediated their chemotaxis ( Changes to chemokine levels may have relevance to neurodegenerative diseases with plasma CCL2 increased in MCI and AD patients (Lee et al., 2018) and correlated to memory decline (Xia et al., 1998)

48,50 NI is a cascade of reactions and immune events, resulting in NDG, and some evidence is developing that OS and NI both contribute to the pathophysiology, onset and progression of NDG

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At 18 h after transfection, medium was replaced and cells were cultured for an additional 30 h prior to incubations

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Our identification of VRK2-mediated SLC7A11 trafficking suggests a potential immune evasion mechanism, as SLC7A11-high tumors often display T cell exclusion phenotypes [37], warranting future investigation into whether VRK2 expression could predict therapeutic response to combined ferroptosis inducers and immune checkpoint inhibitors