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World J Clin Oncol (2016) 7(1):12230

Karunaratne SH, Hemingway J, Jayawardena KG, Dassanayaka V, Vaughan A

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Why its a concern : For individuals with hypertension, arrhythmias, atherosclerosis, or a history of heart attack, this sudden spike in cardiovascular activity could trigger adverse events, such as: Heart palpitations Angina (chest pain) In extreme cases, cardiac arrest Recommendation : People with known cardiovascular issues should consult their physician before trying cold exposure

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Comparing Safety and Side Effects This is the one area where AHK-Cu vs minoxidil isn't close