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Statements Author contributions WL and YL wrote the manuscript and drew the figures

Vitamin D3 regulates and corrects calcium and phosphate metabolism in blood and plays an important role in the uptake of calcium and phosphate from the intestines

This binding action directly stimulates the Leydig cells to produce testosterone, essentially jump-starting the bodys natural production

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[129] [130] Later steps, especially the incorporation of the additional methyl groups of its structure, were investigated using 13 C methyl-labelled S-adenosyl methionine