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The conditions complex pathology, involving both inflammation and structural changes to the joint capsule, may respond differently depending on the stage when treatment begins

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This is due to the fact that H 2 O 2 can quickly and readily diffuse through cell membranes, primarily through aquaporins (AQPs) 29,30 , as well as between neighbouring cells through gap junctions hemichannels composed of connexins which facilitate the transfer of molecules 13 kDa large such as ROS between cells to propagate oxidative signals 31

10.1016/S0165-022X(01)00207-X J