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However, it can be manifested with the classical form of malarial fever, cerebral malaria, or malaria-induced anemia (MIA) and is responsible for one-third of malaria-associated deaths [401]

Many studies have demonstrated that elevated UA level in humans is an independent risk factor for hypertension [ , diabetes [ , cardiovascular disease [ , endothelial dysfunction [ , coronary artery calcification [ , vascular damage [ , obesity and metabolic syndrome

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These factors collectively contribute to further cellular and tissue damage, as well as apoptosis (74)