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Increased intracellular calcium inhibits enzymes responsible for the distribution of phospholipids in plasma membranes and the release of cytochrome C and apoptosis-inducing factors, triggering neuronal apoptotic death, suppressing neurotransmission, and cognitive dysfunction (Bezprozvanny and Mattson 2018)

There are also situations where the right move is to wait or get clearance first

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10.3389/fphar.2020.606759 8 ChaoJ.HuoT