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High expression and activation of SREBPs have been reported in various cancers and have been shown to promote tumor growth (Cheng et al., Amino Acid Metabolism and Epigenetics Epigenetic modification can regulate gene expression by activating or inhibiting gene transcription without changing the DNA sequence, ultimately affecting embryonic development, stem cell differentiation, senescence, and tumorigenesis (Brien et al., 2017

Intracellular unesterified fatty acids must first undergo thio-esterification to coenzyme A, a process catalysed by acyl-CoA synthases and consuming the equivalent of two ATP, with formation of acyl-CoAs, i.e., to activate fatty acids

The link between GST overexpression, especially with respect to GSTP1, and anticancer drug resistance has been extensively studied

Biochem J 1964

2019;8:e012994

Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy caucasians using a saliva-based caffeine test