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The results showed that the biological activity of AXA1125 was greater in patients with T2D, compared with placebo

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2)

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Research has shown that chronic hyperglycemia leads to OS and inflammation, which contribute to the onset and progression of DM2, as well as its associated complications, including renal and cardiovascular diseases (Pickering et al., 2018)

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Collectively, this work proposes an LDH-based strategy that concurrently alleviates pathological acidosis, oxidative stress, mitochondrial dysfunction, and macrophage polarization imbalance, providing a potential nanotherapeutic approach for OA management