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In the future, its application techniques should be optimized, and its clinical therapeutic potential should be further explored to achieve broader medical applications

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These phosphorylated ubiquitin molecules bind to and recruit Parkin, which is then phosphorylated and activated by PINK1

3.1.1 CSF1R inhibitors CSF1R, a type III protein tyrosine kinase receptor, is widely expressed by TAMs ( 3.1.2 ANG2 inhibitors ANG2 is an angiogenic factor that promotes vascular destabilization and leakage by binding to the tyrosine-protein kinase receptor TIE2 ( 3.1.3 CXCR4 inhibitors CXCR4 is a transmembrane G-protein coupled-receptor activated by CXCL12, which is involved in tumor growth, invasion, angiogenesis, and TAM recruitment via the activation of signaling pathways such as MEK/ERK and PI3K/mTOR ( 3.2 TAM repolarization TAMs exhibit a high level of plasticity, meaning that promoting a shift between M2 and M1 phenotypes is a potential strategy for treating GBM

Krishnaswamy S, Kanteti R, Duke-Cohan JS, Loganathan S, Liu W, Ma PC, et al

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