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doi:10.4103/jrms.JRMS_862_18 De Bruyn E, Gulbis B, Cotton F

Retatrutide (weight loss - investigational) Article: Retatrutide for Weight Loss (Investigational) Retatrutide is an experimental peptide that activates three metabolic receptorsGLP-1 (reduces appetite, slows digestion), GIP (improves insulin response) and glucagon (burns fat and calories)

Tirzepatides co-agonist activity leads to superior glucose-lowering and weight-loss effects compared to GLP-1 receptor agonists alone Muller, Nature Reviews Drug Discovery Originally developed by Eli Lilly and marketed under the brand name Mounjaro , tirzepatide was first approved by the FDA in 2022 for type 2 diabetes

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