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A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19

Following translation, ATG4 processes pro-LC3 to reveal the glycine residue at the C-terminus to facilitate downstream conjugation events that convert LC3-I to LC3-II (137)

The question has always been whether the effect translates to meaningful human fat loss and the human trial data is more modest

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CD36 is the main pathway of FA uptake and is highly expressed in all kidney cells[122]