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Furthermore, its rich composition of negatively charged molecules, such as heparan sulfate proteoglycans, creates a significant electrostatic barrier that impedes the filtration of anionic macromolecules and nanoparticles while facilitating the passage of similarly sized cationic species [51]

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Collectively, these findings demonstrate that USP13 stabilizes SOCS1 by removing K63-linked ubiquitination, thereby restraining excessive JAK-STAT activation and reversing resistance to PD-1 therapy in MSI-H CRC

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