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However, inhibition of fungal glutaminases at high salt concentrations during fermentation leads to unwanted conversion of glutamine to pyroglutamic acid

References used to create the figure and discussed in more detail below

doi: 10.1016/j.dental.2016.11.003 53

Pall proposed that MCS had a toxicological and biochemical cause, and that "seven individual chemicals or chemical classesorganophosphorus/carbamate, organochloride and pyrethroid pesticides, organic solvents, carbon monoxide, hydrogen sulphide and mercury/mercurial compoundscould initiate MCS through their ability to increase N-methyl-D-aspartate (NMDA) receptor activity." [4] [7] Pall hypothesized that overactivity of the NMDA receptors, coupled with stress-related increases in nitric oxide and the oxidative product peroxynitrite (known as the NO/ONOO cycle) caused MCS symptoms and worsened the condition

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