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Supporting this, Wang et al (110) found that TSA notably improved cardiac function in two-kidney, two-clip (2K2C) hypertensive rats [reducing left ventricular end-diastolic pressure and increasing ejection fraction and left ventricular fractional shortening (LVFS)], while attenuating myocardial hypertrophy and fibrosis, independent of its antihypertensive effect (no notable impact on blood pressure) (110)

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260,261 The Neh2 domain contains two motifs (i.e., DLG and ETGE), which are essential for the interaction between Nrf2 and its negative regulator, Kelch-like ECH associated protein (Keap) 1

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Acknowledgments We thank the Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP) grants numbers 2020/14426-3 and 2024/18725-6 and Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq) grant number 306023/2022-9 and Fundao Coordenao de Aperfeioamento do Pessoal do Ensino Superior, CAPES), from Brazil Finance code 001