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This translational relevance is already evident in lipid nanoparticle formulations used for mRNA delivery, where efficient encapsulation, protection of nucleic acid cargo, and intracellular release are central determinants of vaccine performance

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Respir Med 95(12):935942

The histamine is still released

Taken together, our results demonstrate that lipid peroxidation induces iron overload in iRPE cells and that TF protects these cells from the oxidative, inflammatory, and ferroptotic damage induced by 4HNE, which recapitulates the features of GA