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Synthesis of CoQcoumarin conjugates 2-(Hydroxymethyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione 45 (43 mg, 0.20 mmol) and 7-(diethylamino)-2-oxo-2 H -chromene-3-carbonyl chloride 46 (67 mg, 0.24 mmol) were dissolved in CH 2 Cl 2 (2 ml), followed by the addition of Et 3 N (40 l, 0.003 mol) and N , N -dimethylpyridin-4-amine (3 mg, 0.024 mmol)

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Furthermore, reduced glutathione can also mitigate the oxidative stress produced by enzymes in phase I detoxification in the liver

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PubMed European Association for the Study of the Liver

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