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It arises from an abnormally expanded CAG trinucleotide repeat encoding the elongated polyglutamine (polyQ) within exon 1 of Huntingtin ( HTT ) gene, which results in the production of toxic mutant huntingtin proteins (mHTT) that accumulate in neurons, particularly in the striatum and cortex ( HTT gene normally contains 10 to 35 CAG trinucleotide repeats, while HD patients exhibit more than 36 repeats

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(2020) Comparison of the effect of clarithromycin triple therapy with or without N-acetylcysteine in the eradication of Helicobacter pylori : a randomized controlled trial