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Diabetes 71 (3), 424439

It also contributes to amino acid metabolism, supporting protein synthesis and other metabolic pathways crucial for cellular growth and function

There is mounting evidence for the role of oxidative stress in the pathophysiology of depression

Acknowledgements This work was financially supported by the NSFC (T2422030 (WL), 82172081 (J.Q.) and 32471462 (J.Q.)), CAMS Initiative for Innovative Medicine (2021-I2M-1-043 (W.L.)), the Science and Technology Program of Tianjin, China (22JCYBJC01000 (W.L.) and 22JCQNJC01640 (J.Q.)), and the Fundamental Research Funds for the Central Universities (2021-RC350-006 (W.L.))

This limitation makes conventional vitamin C a poor candidate for therapeutic conditions that demand high absorption vitamin C for sustained or elevated plasma concentrations, such as immune modulation, oxidative stress recovery, and surgical healing

Helix Decision Constant = -100 Extended Decision Constant = -75 Turn Decision Constant = 0 coil Decision Constant = 0 Amino Acids in Helix Conformation H = 20 69.0% Amino Acids in Extended Conformation X = 3 10.3% Amino Acids in Turn Conformation T = 6 20.7% Amino Acids in coil Conformation C = 0 0.0% RVCPRILMECKKDSDCLAECVCLEHGYCG XXTHXHHHHHHHHHHHHHHHHHHHTTTTT Fig