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On paper, one peptide favouring angiogenesis and cytoprotection while the other favours cell migration and actin dynamics looks complementary which is why researchers find the pairing interesting

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Furthermore, we revealed that co-administration of EPI and F--DDB-derivative (ip, once every other day for 14 days) significantly increased the therapeutic efficacy of EPI (2.0 mg/kg) or F--DDB-derivative (20.0 mg/kg) in mice harboring MDA-MB-468 cell xenografts without additional cardiotoxicity compared to that in EPI monotherapy group

2.4 Muscle proteome Frozen gastrocnemius tissue from the right hindlimb was crushed with a pestle and placed in homogenization buffer (1% Triton X-100, 50 mM HEPES, 12 mM Na pyrophosphate, 100 mM NaF, 10 mM EDTA, protease inhibitor, phosphatase inhibitor) with a stainless-steel bead

The peptide that does penetrate stays mostly local, limiting systemic effects

The steps for the synthesis of EPS by L