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The biological significance of the IGF-1 was most strikingly demonstrated when its expression was knocked out by homologous recombination techniques

Results Kitl/KITLG protein is expressed in IGF target cells and tissues We investigated Kitl/KITLG protein expression in IGF1R-expressing gastrointestinal smooth muscles [18,20,22], LX-2 hepatic stellate cells [24] and GIST cell lines (see ref [16]

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1998 Raun K, Hansen BS, Johansen NL et al