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Decreased carnitine resulting from knockdown of TMLHE also suppressed pan-acetylation of histones H3 and H4, which was not rescued by KG (Fig

However, due to the brains high oxygen consumption and lipid-rich environment, it is particularly vulnerable to oxidative stress when ROS levels exceed antioxidant defenses

Kim, D., Kim, D., Kim, H.-K., Jeon, E., Sung, M., Sung, S.-E., Choi, J.-H., Lee, Y., Kang, K.-K., & Lee, S

selectively overexpressed SLC7A11 in the myocardium and found that it can increase cellular GSH levels and prevent FTH deficiency-mediated iron death [76]