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Cortisol clearance is through a variety of enzyme pathways expressed in many tissues

[ref] Autoimmune diseases vary widely in the immune response, and MS may be an outlier in responding negatively to increasing BH4

L.LerroA.AndrakeM.et al (2013)

The relative expression of OsVTE5_1 , OsVTE5_2 , OsVTE5_3 , and OsVTE5_4 increased in roots by 2.43-, 2.13-, 2.57-, and 2.20-fold, respectively, and in shoots by 2.64-, 3.88-, 3.09-, and 3.63-fold, respectively

CL is synthesized in the mitochondrial inner membrane, or IM, and a fraction of CL is transported to the OM

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