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European Journal of Pharmaceutical Sciences, October 2015, pages 7989 9

(64) demonstrated that persimmon oligoproanthocyanidins mitigate skin inflammatory responses by inhibiting the activation of the NF-kB signaling pathway in UVB-damaged human keratinocyte HaCaT cells and reducing the expression of inflammatory cytokines, including TNF- and IL-6

Reactive oxygen generated by Nox1 triggers the angiogenic switch

- Strengthens skin barrier and protects against environmental stressors

Fe-MnO(2) nanosheets loading dihydroartemisinin for ferroptosis and immunotherapy

In addition, albumin nanoparticles can bypass the hENT1-dependent uptake pathway due to their natural targeting (binding to the tumor microenvironment through SPARC protein) and unique transmembrane mechanisms (such as gp60 receptor mediated transport), directly increasing the concentration of gemcitabine in resistant tumor cells, and have shown advantages in overcoming hENT1-deficient resistance in pancreatic cancer and bladder cancer models (Bartkowski et al., 2024