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A follow up developmental toxicity study in rats with further time points to evaluate pup bone development from postnatal day 2 to adulthood was performed with esomeprazole magnesium at oral doses of 280 mg/kg/day (about 68 times an oral human dose of 40 mg on a body surface area basis) where esomeprazole administration was from either gestational day 7 or gestational day 16 until parturition

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103 It is worth noting that the barrel-stave model cannot explain the membrane disruption effect of AMPs with fewer than 23 amino acids as AMPs need to be long enough to pass through the cell membrane in this model

Zhao et al., 2022)

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