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Mol Ther (2021) 29(4):151228

doi: 10.1056/NEJMoa1007302 62

Finally, we discuss the effects of glutamine blockade on the tumor microenvironment and explore strategies to maximize the utility of glutamine blockers as a cancer treatment

Inflammation Hyperglycemia, metabolic disorder and abnormal hemodynamics can cause cellular injury and induce the inflammatory mediators, including tumor necrosis factor- (TNF-), interleukin-6 (IL-6), chemokines and adhesion molecules, etc