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Ghauri FY, McLean AE, Beales D, Wilson ID, Nicholson JK: Induction of 5-oxoprolinuria in the rat following chronic feeding with N-acetyl 4-aminophenol (paracetamol)

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Native GHRH is biologically active but clinically awkward: its half-life of only a few minutes makes sustained stimulation of the GH axis difficult

But overdose effects can return once it wears off

For the RRM1 knockdown condition, reverse transfection reagent was prepared on top of glass coverslips in six-well dishes using either non-targeting control siRNAs, or siRNA pools targeting human RRM1 , as described above

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